Tau-441 (2N4R) P301S Mutant Mo...
- Article
- Tau-441 (2N4R) P301S Mutant Monomers
- Product Number
- SPR-327E
- Supplier
- StressMarq Biosciences
- Size
- 5 x 100 ug
- Description
- Tau-441, also known as the 2N4R isoform of the microtubule-associated protein tau (MAPT), is the longest isoform expressed in the adult human brain. It plays a critical role in stabilizing microtubules and maintaining neuronal structure and function. Under physiological conditions, tau monomers dynamically bind microtubules, supporting axonal transport and synaptic integrity. The P301S mutation, a proline-to-serine substitution at residue 301, is associated with familial frontotemporal dementia and other tauopathies. This mutation alters the conformation and biochemical properties of tau monomers, reducing their affinity for microtubules and increasing their susceptibility to misfolding and aggregation. P301S mutant monomers exhibit enhanced nucleation potential, facilitating the formation of toxic oligomers and fibrils that disrupt neuronal homeostasis. These misfolded tau species interfere with cytoskeletal dynamics, impair axonal transport, and activate neuroinflammatory pathways, contributing to progressive neurodegeneration. In transgenic models, P301S tau monomers initiate early pathological changes, including synaptic loss, mitochondrial dysfunction, and cognitive decline, even before the appearance of mature neurofibrillary tangles. Understanding the molecular behavior of P301S mutant tau monomers is essential for developing targeted therapies. Strategies aimed at stabilizing tau's native conformation, inhibiting early aggregation events, or enhancing clearance mechanisms are under investigation to mitigate tau-driven neurodegeneration. Tau-441 P301S mutant monomers represent a critical early target in the cascade of tauopathy progression, offering valuable insights for therapeutic intervention and biomarker development.
- Category
- Proteins, Peptides and Small Molecules
- Product Group
- Proteins
- Application
- Func, In Vivo Assay, SDS-PAGE, WB
- Purity
- >95%
- Formulation
- 10 mM HEPES, 100 mM NaCl pH 7.4
- Molecular Weight
- ~45.8 kDa
- Synonyms
- DDPAC; FTDP-17; G protein beta1/gamma2 subunit-interacting factor 1; MAPTL; microtubule-associated protein tau; MSTD; MTBT1; MTBT2; neurofibrillary tangle protein; paired helical filament-tau; PHF-tau; PPND; PPP1R103; protein phosphatase 1, regulatory subunit 103; TAU; tau-40
- Unigene ID
- 4137
- Gene Symbols
- MAPT
- Shipping Temperature
- DRY ICE
- Estimated Delivery Time:
- 5 Business Days
- Supplier URL
- Visit supplier product page
