Tau-441 (2N4R) P301S Mutant Mo...
- Article
- Tau-441 (2N4R) P301S Mutant Monomers (Baculovirus/Sf9)
- Product Number
- SPR-473B
- Supplier
- StressMarq Biosciences
- Size
- 100 ug
- Description
- Tau protein, encoded by the MAPT gene (UniProt ID: P10636), is a microtubule-associated protein critical for maintaining neuronal architecture and intracellular transport. The Tau-441 isoform (2N4R), the longest adult brain variant, includes two N-terminal inserts and four microtubule-binding repeats, making it highly relevant in the context of tauopathies. The P301S mutation, located within the microtubule-binding domain, alters Tau's conformation and increases its tendency to misfold. While aggregated forms such as fibrils are well-known contributors to neurodegeneration, recent research highlights the importance of monomeric P301S Tau in initiating pathological cascades. These monomers exhibit altered biochemical properties, including reduced microtubule binding and increased susceptibility to post-translational modifications, which can prime them for aggregation and toxicity. Tau-441 P301S mutant monomers serve as a critical starting point for in vitro and in vivo studies exploring early-stage Tau dysfunction. Their use enables researchers to dissect the molecular events leading to aggregation, synaptic impairment, and neuronal death. These monomers also provide a baseline for evaluating therapeutic agents aimed at stabilizing native Tau, preventing misfolding, and interrupting disease progression before fibril formation. By modeling the earliest phases of Tau pathology, Tau-441 P301S mutant monomers offer a high-resolution lens into the mechanisms of neurodegenerative disease and support the development of preventative strategies in tauopathy research.
- Category
- Proteins, Peptides and Small Molecules
- Product Group
- Proteins
- Application
- Func, In Vivo Assay, SDS-PAGE, WB
- Purity
- >95%
- Formulation
- PBS
- Molecular Weight
- ~45.8 kDa
- Synonyms
- DDPAC; FTDP-17; G protein beta1/gamma2 subunit-interacting factor 1; MAPTL; microtubule-associated protein tau; MSTD; MTBT1; MTBT2; neurofibrillary tangle protein; paired helical filament-tau; PHF-tau; PPND; PPP1R103; protein phosphatase 1, regulatory subunit 103; TAU; tau-40
- Unigene ID
- 4137
- Gene Symbols
- MAPT
- Shipping Temperature
- DRY ICE
- Estimated Delivery Time:
- 5 Business Days
- Supplier URL
- Visit supplier product page
