Tau-441 (2N4R) P301S Mutant Pr...
- Article
- Tau-441 (2N4R) P301S Mutant Pre-formed Fibrils
- Product Number
- SPR-329B
- Supplier
- StressMarq Biosciences
- Size
- 100 ug
- Description
- Tau-441, the longest isoform of the microtubule-associated protein tau (MAPT), contains two N-terminal inserts and four microtubule-binding repeats (2N4R). This isoform plays a vital role in stabilizing microtubules and maintaining neuronal architecture. The P301S mutation, a proline-to-serine substitution at residue 301, is linked to familial tauopathies and significantly enhances tau's aggregation propensity. Pre-formed fibrils (PFFs) generated from Tau-441 P301S mutant proteins replicate the structural and pathological features of tau aggregates found in neurodegenerative diseases such as frontotemporal dementia and Alzheimer's disease. These fibrils act as potent seeds, inducing the misfolding and aggregation of endogenous tau in a prion-like manner. This seeding mechanism drives the spread of tau pathology across neural circuits, leading to synaptic dysfunction, neuroinflammation, and progressive neuronal loss. Experimental models employing P301S mutant PFFs have demonstrated their ability to initiate early tau pathology, including the formation of neurofibrillary tangles and tau-positive inclusions. These models are instrumental in dissecting the molecular mechanisms of tau propagation and identifying therapeutic targets. Tau-441 P301S mutant PFFs are essential tools for studying the dynamics of tau aggregation and its role in neurodegeneration. Their use in preclinical research accelerates the development of disease-modifying therapies aimed at halting tau spread, enhancing clearance, and restoring neuronal function in tauopathies.
- Category
- Proteins, Peptides and Small Molecules
- Product Group
- Proteins
- Application
- Func, In Vivo Assay, SDS-PAGE, WB
- Purity
- >95%
- Formulation
- 10 mM HEPES, 100 mM NaCl pH 7.4
- Molecular Weight
- ~45.8 kDa
- Synonyms
- DDPAC; FTDP-17; G protein beta1/gamma2 subunit-interacting factor 1; MAPTL; microtubule-associated protein tau; MSTD; MTBT1; MTBT2; neurofibrillary tangle protein; paired helical filament-tau; PHF-tau; PPND; PPP1R103; protein phosphatase 1, regulatory subunit 103; TAU; tau-40
- Unigene ID
- 4137
- Gene Symbols
- MAPT
- Shipping Temperature
- DRY ICE
- Estimated Delivery Time:
- 5 Business Days
- Supplier URL
- Visit supplier product page
