Tau-441 (2N4R) Wild-Type Monom...
- Article
- Tau-441 (2N4R) Wild-Type Monomers
- Product Number
- SPR-479E
- Supplier
- StressMarq Biosciences
- Size
- 5 x 100 ug
- Description
- Tau protein, encoded by the MAPT gene (UniProt ID: P10636), is a microtubule-associated protein essential for stabilizing neuronal microtubules and maintaining axonal transport. The Tau-441 isoform (2N4R), the longest variant expressed in the adult human brain, contains two N-terminal inserts and four microtubule-binding repeats, making it a key reference in tauopathy research. In its wild-type monomeric form, Tau-441 exhibits native folding and functional microtubule-binding capacity. This form serves as a critical baseline for understanding how mutations, post-translational modifications, and environmental stressors disrupt Tau's structure and function, leading to pathological aggregation. Studying wild-type monomers allows researchers to pinpoint the earliest molecular events that precede fibril formation and neurodegeneration. Tau-441 wild-type monomers are widely used in biochemical, structural, and cellular assays to investigate Tau's physiological roles and its transition into disease-associated conformers. These studies inform the development of therapeutic strategies aimed at preserving Tau's native state, preventing misfolding, and maintaining neuronal health. As a foundational model, Tau-441 wild-type monomers provide essential insights into Tau biology and offer a reference framework for evaluating the impact of disease-linked variants in neurodegenerative research.
- Category
- Proteins, Peptides and Small Molecules
- Product Group
- Proteins
- Application
- Func, In Vivo Assay, SDS-PAGE, WB
- Purity
- >95%
- Formulation
- 10 mM HEPES, 100 mM NaCl pH 7.4
- Molecular Weight
- ~45.85 kDa
- Synonyms
- DDPAC; FTDP-17; G protein beta1/gamma2 subunit-interacting factor 1; MAPTL; microtubule-associated protein tau; MSTD; MTBT1; MTBT2; neurofibrillary tangle protein; paired helical filament-tau; PHF-tau; PPND; PPP1R103; protein phosphatase 1, regulatory subunit 103; TAU; tau-40
- Unigene ID
- 4137
- Gene Symbols
- MAPT
- Shipping Temperature
- DRY ICE
- Estimated Delivery Time:
- 5 Business Days
- Supplier URL
- Visit supplier product page
