Tau (K18) Delta K280 Mutant Mo...
- Article
- Tau (K18) Delta K280 Mutant Monomers
- Product Number
- SPR-476C
- Supplier
- StressMarq Biosciences
- Size
- 2 x 100 ug
- Description
- Tau protein, encoded by the MAPT gene (UniProt ID: P10636), is essential for stabilizing microtubules and maintaining neuronal integrity. The K18 fragment of Tau comprises the four microtubule-binding repeat domains, representing the aggregation-prone core of the full-length protein. The ΔK280 mutation, involving the deletion of lysine at position 280, significantly enhances Tau's aggregation propensity. In its monomeric form, Tau (K18) ΔK280 exhibits altered structural dynamics and reduced microtubule affinity, making it a powerful tool for studying the earliest molecular events in tauopathy. These monomers serve as a foundational model for investigating how subtle conformational changes can initiate misfolding, seeding, and neurotoxicity. Tau (K18) ΔK280 mutant monomers are widely used in biochemical and cellular assays to explore the transition from native Tau to pathogenic aggregates. Their minimal structure allows for high-resolution analysis of post-translational modifications, protein-protein interactions, and early aggregation kinetics. This model is particularly valuable for identifying therapeutic targets that stabilize Tau or prevent its pathological transformation. By capturing the initial stages of Tau dysfunction, Tau (K18) ΔK280 mutant monomers provide a streamlined and disease-relevant platform for advancing neurodegenerative research and accelerating the development of preventative interventions.
- Category
- Proteins, Peptides and Small Molecules
- Product Group
- Proteins
- Application
- Func, In Vivo Assay, SDS-PAGE, WB
- Purity
- >95%
- Formulation
- PBS
- Molecular Weight
- ~15 kDa
- Synonyms
- DDPAC; FTDP-17; G protein beta1/gamma2 subunit-interacting factor 1; MAPTL; microtubule-associated protein tau; MSTD; MTBT1; MTBT2; neurofibrillary tangle protein; paired helical filament-tau; PHF-tau; PPND; PPP1R103; protein phosphatase 1, regulatory subunit 103; TAU; tau-40
- Unigene ID
- 4137
- Gene Symbols
- MAPT
- Shipping Temperature
- DRY ICE
- Estimated Delivery Time:
- 5 Business Days
- Supplier URL
- Visit supplier product page
