Tau (K18) Delta K280 Mutant Pr...
- Article
- Tau (K18) Delta K280 Mutant Pre-formed Fibrils
- Product Number
- SPR-477B
- Supplier
- StressMarq Biosciences
- Size
- 100 ug
- Description
- Tau protein, encoded by the MAPT gene (UniProt ID: P10636), plays a central role in stabilizing microtubules and maintaining neuronal integrity. The K18 fragment of Tau, comprising the four microtubule-binding repeat domains, represents the aggregation-prone core of the full-length protein and is widely used in tauopathy research. The ΔK280 mutation, involving the deletion of lysine at position 280, dramatically increases Tau's tendency to misfold and assemble into β-sheet-rich fibrils. Pre-formed fibrils (PFFs) generated from Tau (K18) ΔK280 mutant protein closely mimic the structural and biochemical properties of pathological Tau aggregates found in neurodegenerative diseases such as Alzheimer's disease and frontotemporal dementia. These mutant PFFs are instrumental in modeling Tau seeding, propagation, and neurotoxicity in vitro and in vivo. Their reproducibility and disease relevance make them ideal for studying the prion-like behavior of Tau, as well as for evaluating therapeutic strategies aimed at inhibiting aggregation, enhancing clearance, or blocking intercellular transmission. Tau (K18) ΔK280 PFFs provide a robust and scalable platform for mechanistic studies, biomarker discovery, and drug development, accelerating progress in the fight against tauopathies and related neurodegenerative disorders.
- Category
- Proteins, Peptides and Small Molecules
- Product Group
- Proteins
- Application
- Func, In Vivo Assay, SDS-PAGE, WB
- Purity
- >95%
- Formulation
- PBS
- Molecular Weight
- ~15 kDa
- Synonyms
- DDPAC; FTDP-17; G protein beta1/gamma2 subunit-interacting factor 1; MAPTL; microtubule-associated protein tau; MSTD; MTBT1; MTBT2; neurofibrillary tangle protein; paired helical filament-tau; PHF-tau; PPND; PPP1R103; protein phosphatase 1, regulatory subunit 103; TAU; tau-40
- Unigene ID
- 4137
- Gene Symbols
- MAPT
- Shipping Temperature
- DRY ICE
- Estimated Delivery Time:
- 5 Business Days
- Supplier URL
- Visit supplier product page
