Tau (K18) P301L Mutant Monomer...
- Article
- Tau (K18) P301L Mutant Monomers
- Product Number
- SPR-328B
- Supplier
- StressMarq Biosciences
- Size
- 100 ug
- Description
- Tau is a microtubule-associated protein encoded by the MAPT gene, essential for stabilizing neuronal microtubules and maintaining axonal transport. The K18 fragment of tau, comprising the four microtubule-binding repeat domains, is a widely used model for studying tau aggregation. Within this domain, the P301L mutation-where proline is substituted by leucine at position 301-is strongly associated with familial frontotemporal dementia and other tauopathies. Tau (K18) P301L mutant monomers exhibit altered conformational dynamics that reduce microtubule binding affinity and increase aggregation propensity. These structural changes promote the formation of toxic oligomers and fibrils, which disrupt cytoskeletal integrity, impair axonal transport, and trigger neuroinflammatory responses. Even in their monomeric state, P301L tau variants display enhanced seeding activity, initiating pathological cascades that precede overt neurofibrillary tangle formation. Experimental models using P301L mutant tau monomers reveal early synaptic dysfunction, mitochondrial stress, and progressive neuronal loss. These monomers also influence tau phosphorylation patterns and proteolytic processing, contributing to the accumulation of neurotoxic species. Their ability to self-assemble and propagate misfolded tau across neural networks underscores their role as primary instigators of tau-mediated neurodegeneration. Targeting the early misfolding and aggregation of P301L tau monomers offers a promising therapeutic strategy. Interventions aimed at stabilizing native tau structure, inhibiting seed formation, or enhancing clearance pathways are under active investigation to halt disease progression in tauopathies.
- Category
- Proteins, Peptides and Small Molecules
- Product Group
- Proteins
- Application
- Func, In Vivo Assay, SDS-PAGE, WB
- Purity
- >95%
- Formulation
- 10 mM HEPES, 100 mM NaCl pH 7.4
- Molecular Weight
- ~15.1 kDa
- Synonyms
- DDPAC; FTDP-17; G protein beta1/gamma2 subunit-interacting factor 1; MAPTL; microtubule-associated protein tau; MSTD; MTBT1; MTBT2; neurofibrillary tangle protein; paired helical filament-tau; PHF-tau; PPND; PPP1R103; protein phosphatase 1, regulatory subunit 103; TAU; tau-40
- Unigene ID
- 4137
- Gene Symbols
- MAPT
- Shipping Temperature
- DRY ICE
- Estimated Delivery Time:
- 5 Business Days
- Supplier URL
- Visit supplier product page
