Tau (K18) P301L Mutant Pre-for...
- Article
- Tau (K18) P301L Mutant Pre-formed Fibrils
- Product Number
- SPR-330B
- Supplier
- StressMarq Biosciences
- Size
- 100 ug
- Description
- Tau is a microtubule-associated protein encoded by the MAPT gene, essential for maintaining neuronal structure and axonal transport. The K18 fragment, comprising the four microtubule-binding repeat domains of tau, serves as a minimal model for studying tau aggregation. The P301L mutation, a proline-to-leucine substitution at residue 301, is linked to familial frontotemporal dementia and significantly enhances tau's aggregation propensity. Pre-formed fibrils (PFFs) generated from Tau (K18) P301L mutant proteins replicate key features of pathological tau aggregates observed in tauopathies. These fibrils act as potent seeds, initiating the misfolding and aggregation of endogenous tau in a prion-like fashion. This seeding process drives the spread of tau pathology across neuronal networks, contributing to synaptic dysfunction, neuroinflammation, and progressive neurodegeneration. In experimental models, Tau (K18) P301L PFFs induce early tau pathology, including the formation of neurofibrillary tangles and tau-positive inclusions. These models are instrumental in elucidating the molecular mechanisms underlying tau propagation, cellular toxicity, and disease progression. The P301L mutation also influences tau's interaction with microtubules and its susceptibility to post-translational modifications, further exacerbating its pathogenic potential. Tau (K18) P301L mutant PFFs are critical tools for preclinical research, enabling high-throughput screening of therapeutic candidates aimed at inhibiting tau aggregation, enhancing clearance, and restoring neuronal function. Their use accelerates the development of targeted interventions for tau-driven neurodegenerative diseases.
- Category
- Proteins, Peptides and Small Molecules
- Product Group
- Proteins
- Application
- Func, In Vivo Assay, SDS-PAGE, WB
- Purity
- >95%
- Formulation
- 10 mM HEPES, 100 mM NaCl pH 7.4
- Molecular Weight
- ~15.1 kDa
- Synonyms
- DDPAC; FTDP-17; G protein beta1/gamma2 subunit-interacting factor 1; MAPTL; microtubule-associated protein tau; MSTD; MTBT1; MTBT2; neurofibrillary tangle protein; paired helical filament-tau; PHF-tau; PPND; PPP1R103; protein phosphatase 1, regulatory subunit 103; TAU; tau-40
- Unigene ID
- 4137
- Gene Symbols
- MAPT
- Shipping Temperature
- DRY ICE
- Estimated Delivery Time:
- 5 Business Days
- Supplier URL
- Visit supplier product page
