Tau Truncated Fragment (AA297-...
- Article
- Tau Truncated Fragment (AA297-391) (dGAE) Pre-formed Fibrils
- Product Number
- SPR-461B
- Supplier
- StressMarq Biosciences
- Size
- 100 ug
- Description
- Tau protein, encoded by the MAPT gene (UniProt ID: P10636), plays a pivotal role in stabilizing neuronal microtubules and maintaining axonal integrity. In neurodegenerative disorders such as Alzheimer's disease and frontotemporal dementia, Tau undergoes pathological misfolding and aggregation into insoluble fibrils, forming neurofibrillary tangles-a hallmark of tauopathies. The dGAE fragment of Tau (residues 297-391) encompasses the core region of the protein's microtubule-binding domain and is intrinsically prone to self-assembly into β-sheet-rich fibrillar structures. Pre-formed fibrils (PFFs) derived from Tau dGAE serve as a robust and reproducible model for studying the molecular mechanisms of Tau aggregation, seeding, and propagation in vitro and in vivo. These fibrils mimic the structural and biochemical properties of pathological Tau aggregates observed in human brains, enabling researchers to dissect the prion-like behavior of Tau and its role in neurotoxicity. Tau dGAE PFFs are instrumental in evaluating therapeutic strategies aimed at inhibiting fibril formation, blocking intercellular transmission, and enhancing aggregate clearance. Their use accelerates the development of targeted interventions and biomarker discovery, positioning them as a cornerstone in translational neurodegeneration research.
- Category
- Proteins, Peptides and Small Molecules
- Product Group
- Proteins
- Application
- Func, In Vivo Assay, SDS-PAGE, WB
- Purity
- >95%
- Formulation
- 10mM PB pH7.4, 10mM DTT
- Molecular Weight
- 10.165 kDa
- Synonyms
- DDPAC; FTDP-17; G protein beta1/gamma2 subunit-interacting factor 1; MAPTL; microtubule-associated protein tau; MSTD; MTBT1; MTBT2; neurofibrillary tangle protein; paired helical filament-tau; PHF-tau; PPND; PPP1R103; protein phosphatase 1, regulatory subunit 103; TAU; tau-40
- Unigene ID
- 4137
- Gene Symbols
- MAPT
- Shipping Temperature
- DRY ICE
- Estimated Delivery Time:
- 5 Business Days
- Supplier URL
- Visit supplier product page
