Urocortin III (mouse) (trifluo...
- Article
- Urocortin III (mouse) (trifluoroacetate salt)
- Product Number
- 24750-1MG
- Supplier
- Cayman Chemical
- Size
- 1 mg
- Description
- A neuropeptide hormone, expressed in the hypothalamus, brainstem, and LS/BnST as well as the small intestine, pancreatic β-cells, and skin in mice, selectively binds to type 2 CRF receptors (Kis = 5, 1.8, and >100 nM for rat CRF2α, rat CRF2β, and human CRF1, respectively), stimulates cAMP production in CHO cells expressing rat CR2α and mouse CR2β (EC50s = 0.073 and 0.08 nM, respectively), increases exploration in the open field test and decreases latency to enter the lit compartment in the dark-light emergence test, indicating anxiolytic-like activity in mice (20 µg, i.c.v), co-released with insulin to potentiate glucose-stimulated somatostatin release in vitro and in vivo in wild-type mice, depleted from β-cells in mouse and macaque models of type 2 diabetes
- Category
- Proteins, Peptides and Small Molecules
- Product Group
- Inhibitors & Activators
- Purity
- ≥95%
- Formulation
- A lyophilized powder
- Molecular Weight
- 4173.9
- Shipping Temperature
- DRY ICE
- Supplier URL
- Visit supplier product page
