dsDNA Shearase Plus is an endonuclease that cleaves phosphodiester bonds in DNA to yield oligonucleotides with 5,Aeo-phosphate and 3,Aeo-hydroxyl termini. It has a particularly strong preference for dsDNA and generates random-ended DNA fragments of the desired size in a single step. This enzyme is compatible with low volume inputs, thus minimizing sample loss.|Simply control fragment size of dsDNA by adjusting the concentration of dsDNA Shearase Plus.