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CD4 mAb (GK 1.5), InVivoPure+

Article
CD4 mAb (GK 1.5), InVivoPure+
Product Number
AK3602P+-1MG
Supplier
InVivo BioTech Services
Size
1 mg
Description
The monoclonal antibody GK1.5 reacts with the mouse CD4 molecule, a 55 kDa cell surface receptor expressed by the majority of thymocytes, a subpopulation of mature T cells and dendritic cells. CD4 binds to MHC class II on the surface of antigen-presenting cells and plays an important role both in the development of T cells and in the optimal function of mature T cells. In T cells, CD4 associates with the protein tyrosine kinase p56lck via its cytoplasmic tail. The binding of GK1.5 is blocked by the antibody RM4-5, which competes with GK1.5 for the same binding site on the CD4 molecule. GK1.5 significantly increased the proportion of peripheral CD4+CD25+Foxp3+ Treg cells in CD4+ T cells in mice without altering their immunosuppressive function. The antibody profoundly blocks antigen-specific reactive mouse helper T lymphocyte lines of class II MHC.
Category
Antibodies
Product Group
Monoclonal Antibodies
Application
Isol
Host
Mouse
Species reactivity
Mouse
Conjugate
Unconjugated
Clone ID
GK 1.5
Purity
>=95%
Formulation
Clear Liquid, PBS, pH 7.4, 0.2 µm sterile filtered
Immunogen
Animals were immunized with the cloned cytotoxic T lymphocyte lines V4 and 243/2.5. L3T4 is expressed on mouse helper/inducer T cells and is analogous to the human Leu-3/T4 molecule.
Synonyms
L3T; L3T4; Ly-; Ly-4; T-cell differentiation antigen L3T4; T-cell surface antigen T4/Leu-3; T-cell surface glycoprotein CD4
Unigene ID
12504
Gene Symbols
Cd4
Supplier URL
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