CD4 mAb (GK 1.5), InVivoPure+
- Article
- CD4 mAb (GK 1.5), InVivoPure+
- Product Number
- AK3602P+-25MG
- Supplier
- InVivo BioTech Services
- Size
- 25 mg
- Description
- The monoclonal antibody GK1.5 reacts with the mouse CD4 molecule, a 55 kDa cell surface receptor expressed by the majority of thymocytes, a subpopulation of mature T cells and dendritic cells. CD4 binds to MHC class II on the surface of antigen-presenting cells and plays an important role both in the development of T cells and in the optimal function of mature T cells. In T cells, CD4 associates with the protein tyrosine kinase p56lck via its cytoplasmic tail. The binding of GK1.5 is blocked by the antibody RM4-5, which competes with GK1.5 for the same binding site on the CD4 molecule. GK1.5 significantly increased the proportion of peripheral CD4+CD25+Foxp3+ Treg cells in CD4+ T cells in mice without altering their immunosuppressive function. The antibody profoundly blocks antigen-specific reactive mouse helper T lymphocyte lines of class II MHC.
- Category
- Antibodies
- Product Group
- Monoclonal Antibodies
- Application
- Isol
- Host
- Mouse
- Species reactivity
- Mouse
- Conjugate
- Unconjugated
- Clone ID
- GK 1.5
- Purity
- >=95%
- Formulation
- Clear Liquid, PBS, pH 7.4, 0.2 µm sterile filtered
- Immunogen
- Animals were immunized with the cloned cytotoxic T lymphocyte lines V4 and 243/2.5. L3T4 is expressed on mouse helper/inducer T cells and is analogous to the human Leu-3/T4 molecule.
- Synonyms
- L3T; L3T4; Ly-; Ly-4; T-cell differentiation antigen L3T4; T-cell surface antigen T4/Leu-3; T-cell surface glycoprotein CD4
- Unigene ID
- 12504
- Gene Symbols
- Cd4
- Supplier URL
- Visit supplier product page