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Tau-352 (fetal 0N3R) Wild-Type...

Article
Tau-352 (fetal 0N3R) Wild-Type Pre-formed Fibrils
Product Number
SPR-491C
Supplier
StressMarq Biosciences
Size
2 x 100 ug
Description
Alzheimer's Disease (AD) is the most common neurodegenerative disease, affecting 10% of seniors over the age of 65 (1). Tau (tubulin-associated unit) is normally located in the axons of neurons where it stabilizes microtubules. Tauopathies such as AD are characterized by neurofibrillary tangles containing paired helical filaments (PHFs). Brain-specific tau isoforms vary in the number of N-terminal inserts and C- terminal repeat domains due to alternative splicing of exons, only the shortest isoform of tau, 0N3R, is expressed in the fetal brain during neurogenesis (2). Three-repeat (3R) isoforms have been shown to be more prone than four-repeat (4R) isoforms to form oligomers in vitro (3). The β-sheet core of Tau 0N3R fibrilized using heparin differs from all other tau fibril structures known to date (4).
Category
Proteins, Peptides and Small Molecules
Product Group
Proteins
Application
Func, SDS-PAGE, WB
Purity
>95%
Molecular Weight
37 kDa
Synonyms
DDPAC; FTDP-17; G protein beta1/gamma2 subunit-interacting factor 1; MAPTL; microtubule-associated protein tau; MSTD; MTBT1; MTBT2; neurofibrillary tangle protein; paired helical filament-tau; PHF-tau; PPND; PPP1R103; protein phosphatase 1, regulatory subunit 103; TAU; tau-40
Unigene ID
4137
Gene Symbols
MAPT
Shipping Temperature
DRY ICE
Supplier URL
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