Tau-352 (fetal 0N3R) Wild-Type...
- Article
- Tau-352 (fetal 0N3R) Wild-Type Pre-formed Fibrils
- Product Number
- SPR-491XE
- Supplier
- StressMarq Biosciences
- Size
- 500 ug
- Description
- Tau protein, encoded by the MAPT gene (UniProt ID: P10636), is essential for microtubule stabilization and neuronal function. The Tau-352 isoform, also known as 0N3R, is a fetal variant composed of three microtubule-binding repeats and no N-terminal inserts. This isoform is predominantly expressed during early brain development and is replaced by longer adult isoforms postnatally. Pre-formed fibrils (PFFs) generated from wild-type Tau-352 replicate early aggregation events and provide a unique model for studying the structural and functional properties of fetal Tau in the context of neurodegenerative disease. Although less aggregation-prone than adult isoforms, 0N3R Tau can form β-sheet-rich fibrils under pathological conditions, contributing to tauopathy progression. Tau-352 PFFs are used in experimental systems to investigate the mechanisms of Tau seeding, propagation, and neurotoxicity. Their relevance extends to disorders such as Alzheimer's disease and Pick's disease, where altered isoform ratios and early aggregation events are implicated in disease onset. These fibrils enable high-resolution studies of Tau's prion-like behavior and support the development of therapeutic strategies aimed at preventing aggregation and promoting clearance. By modeling the transition from developmental Tau to pathogenic aggregates, Tau-352 wild-type PFFs offer a valuable platform for understanding early-stage tauopathies and advancing neurodegenerative disease research.
- Category
- Proteins, Peptides and Small Molecules
- Product Group
- Proteins
- Application
- Func, SDS-PAGE, WB
- Purity
- >95%
- Formulation
- 10 mM Hepes pH 7.4, 100 mM NaCl
- Molecular Weight
- 37 kDa
- Synonyms
- DDPAC; FTDP-17; G protein beta1/gamma2 subunit-interacting factor 1; MAPTL; microtubule-associated protein tau; MSTD; MTBT1; MTBT2; neurofibrillary tangle protein; paired helical filament-tau; PHF-tau; PPND; PPP1R103; protein phosphatase 1, regulatory subunit 103; TAU; tau-40
- Unigene ID
- 4137
- Gene Symbols
- MAPT
- Shipping Temperature
- DRY ICE
- Estimated Delivery Time:
- 5 Business Days
- Supplier URL
- Visit supplier product page
