Tau-430 (2N4R) P290S Mutant Mo...
- Article
- Tau-430 (2N4R) P290S Mutant Monomers
- Product Number
- SPR-474C
- Supplier
- StressMarq Biosciences
- Size
- 2 x 100 ug
- Description
- Tau protein, encoded by the MAPT gene (UniProt ID: P10636), is a microtubule-associated protein essential for maintaining neuronal structure and intracellular transport. The Tau-430 isoform (2N4R) includes two N-terminal inserts and four microtubule-binding repeats, representing a key variant expressed in the adult human brain. The P290S mutation, located within the microtubule-binding domain, alters Tau's conformation and reduces its affinity for microtubules. This destabilization promotes early misfolding events, making the monomeric form of Tau-430 P290S a valuable model for studying the initial stages of tauopathy. Unlike aggregated fibrils, mutant monomers provide insight into the pre-aggregation phase, where subtle biochemical changes begin to disrupt neuronal homeostasis. Tau-430 P290S mutant monomers are instrumental in dissecting the molecular mechanisms that precede fibril formation, including aberrant phosphorylation, impaired axonal transport, and synaptic dysfunction. Their use in cellular and biochemical assays enables researchers to identify early biomarkers and therapeutic targets aimed at stabilizing native Tau and preventing pathological transformation. By modeling the earliest molecular disruptions in Tau biology, Tau-430 P290S mutant monomers offer a high-resolution platform for advancing neurodegenerative disease research and accelerating the development of preventative interventions.
- Category
- Proteins, Peptides and Small Molecules
- Product Group
- Proteins
- Application
- Func, In Vivo Assay, SDS-PAGE, WB
- Purity
- >95%
- Formulation
- PBS
- Molecular Weight
- ~45 kDa
- Synonyms
- AI413597; AW045860; microtubule-associated protein tau; Mta; Mtapt; neurofibrillary tangle protein; paired helical filament-tau; PHF-tau; Ta; Tau
- Unigene ID
- 17762
- Gene Symbols
- Mapt
- Shipping Temperature
- DRY ICE
- Estimated Delivery Time:
- 5 Business Days
- Supplier URL
- Visit supplier product page
