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Tau-430 (2N4R) P290S Mutant Mo...

Article
Tau-430 (2N4R) P290S Mutant Monomers
Product Number
SPR-474E
Supplier
StressMarq Biosciences
Size
5 x 100 ug
Description
Alzheimer's Disease (AD) is the most common neurodegenerative disease, affecting 10% of seniors over the age of 65 (1). It was named after Alois Alzheimer, a German scientist who discovered tangled bundles of fibrils where neurons had once been in the brain of a deceased patient in 1907 (2). Tau (tubulin-associated unit) is normally located in the axons of neurons where it stabilizes microtubules. Tauopathies such as AD are characterized by neurofibrillary tangles containing hyperphosphorylated tau fibrils (3). 2N4R, or Tau-441 is the full length tau protein. P301S is a mutation encoded by exon 10 (4) that impairs the ability of tau to assemble microtubules (5).
Category
Proteins, Peptides and Small Molecules
Product Group
Proteins
Application
Func, In Vivo Assay, SDS-PAGE, WB
Purity
>95%
Molecular Weight
~45 kDa
Synonyms
AI413597; AW045860; microtubule-associated protein tau; Mta; Mtapt; neurofibrillary tangle protein; paired helical filament-tau; PHF-tau; Ta; Tau
Unigene ID
17762
Gene Symbols
Mapt
Shipping Temperature
DRY ICE
Supplier URL
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