Tau dGAE (297-391) AD-mimic Pr...
- Article
- Tau dGAE (297-391) AD-mimic Pre-formed Fibrils
- Product Number
- SPR-502C
- Supplier
- StressMarq Biosciences
- Size
- 2 x 100 ug
- Description
- Filamentous tau inclusions are a hallmark of many neurodegenerative diseases, including Alzheimer's disease (AD) and Chronic Traumatic Encephalopathy (CTE), collectively called tauopathies. Advances in Cryo-EM have revealed that tau filaments isolated from individuals with a particular neurodegenerative disease share a distinct tau fold - i.e. an AD-isolated Tau filaments' fold is distinct from a CTE-isolated Tau filaments' fold (1-3). Utilizing Tau filaments with the correct disease-specific fold is an important goal towards better mimicking specific human diseases in cellular and in vivo models. Recent Cryo-EM studies have demonstrated that recombinantly generated Tau dGAE monomers will form the disease-isolated AD or CTE Tau filament folds under highly specific conditions in vitro (4, 5). StressMarq's catalog# SPR-502 Tau dGAE (297-391) AD-mimic PFFs are purified and fibrilized under these exact published conditions that replicate the disease-isolated AD-fold (200 rpm at 37oC in 10 mM PB 10 mM DTT pH 7.4 200 mM MgCl2 for 48 hours).
- Category
- Proteins, Peptides and Small Molecules
- Product Group
- Proteins
- Application
- Func, In Vivo Assay, WB
- Purity
- >95%
- Formulation
- 10mM PB pH 7.4, 10mM DTT, 200mM MgCl2
- Molecular Weight
- 10.165 kDa
- Synonyms
- Neurofibrillary tangle protein; Paired helical filament-tau
- Shipping Temperature
- DRY ICE
- Supplier URL
- Visit supplier product page
