Tau dGAE (297-391) AD-mimic Pr...
- Article
- Tau dGAE (297-391) AD-mimic Pre-formed Fibrils
- Product Number
- SPR-502XE
- Supplier
- StressMarq Biosciences
- Size
- 500 ug
- Description
- Tau dGAE (297-391) represents a truncated segment of the microtubule-associated protein tau, encompassing the core region responsible for pathological aggregation. This fragment includes the repeat domains critical for β-sheet formation and fibrillization, making it a minimal yet potent model for studying tau-driven neurodegeneration. When assembled into pre-formed fibrils (PFFs), Tau dGAE adopts structural features that closely mimic those found in Alzheimer's disease (AD) brain-derived tau aggregates. These AD-mimic PFFs exhibit high seeding efficiency, inducing endogenous tau misfolding and aggregation in cellular and animal models. Their ability to replicate key aspects of tau pathology-including filament morphology, phosphorylation patterns, and neurotoxicity-makes them a powerful tool for mechanistic studies. Tau dGAE AD-mimic PFFs enable researchers to investigate the prion-like propagation of tau aggregates, synaptic dysfunction, and neuronal loss. Their reproducibility and disease relevance support high-throughput screening of anti-tau therapeutics, including aggregation inhibitors, immunotherapies, and modulators of tau clearance pathways. By modeling the structural and functional hallmarks of tau pathology, Tau dGAE AD-mimic PFFs accelerate translational research aimed at halting tau-mediated neurodegeneration. Their use bridges the gap between in vitro biophysics and in vivo disease modeling, offering a robust platform for therapeutic development in Alzheimer's disease and related tauopathies. Advances in Cryo-EM have revealed that tau filaments isolated from individuals with a particular neurodegenerative disease share a distinct tau fold - i.e. an AD-isolated Tau filaments' fold is distinct from a CTE-isolated Tau filaments' fold (1-3). Utilizing Tau filaments with the correct disease-specific fold is an important goal towards better mimicking specific human diseases in cellular and in vivo models. Recent Cryo-EM studies have demonstrated that recombinantly generated Tau dGAE monomers will form the disease-isolated AD or CTE Tau filament folds under highly specific conditions in vitro (4, 5). StressMarq's Tau dGAE (297-391) AD-mimic PFFs are purified and fibrilized under these exact published conditions that replicate the disease-isolated AD-fold (200 rpm at 37oC in 10 mM PB 10 mM DTT pH 7.4 200 mM MgCl2 for 48 hours).
- Category
- Proteins, Peptides and Small Molecules
- Product Group
- Proteins
- Application
- Func, In Vivo Assay, WB
- Purity
- >95%
- Formulation
- 10mM PB pH 7.4, 10mM DTT, 200mM MgCl2
- Molecular Weight
- 10.165 kDa
- Synonyms
- Neurofibrillary tangle protein; Paired helical filament-tau
- Shipping Temperature
- DRY ICE
- Estimated Delivery Time:
- 5 Business Days
- Supplier URL
- Visit supplier product page
